The bacterium Lactobacillus bulgaricus RM1
Lactobacillus bulgaricus RM1
A gift from nature for our health and longevity
Welcome to the world of the unique probiotic strain Lactobacillus bulgaricus RM1 from the treasury of Momchilovtsi – the mystical center of longevity in the Rhodopes!
Origin of Lactobacillus bulgaricus RM1
Lactobacillus bulgaricus RM1 is more than a simple probiotic bacterium.
It is a high-quality strain of the lactic acid bacterium Lactobacillus that brings with it a rich history and outstanding probiotic characteristics.
Natural strain:
-
- Origin and tradition: Lactobacillus bulgaricus RM1 (Lactobacillus bulgaricus RM1) is the first selected and isolated probiotic strain from Momchilovtsi, Central Rhodopes in Bulgaria.
Historically known for its ideal conditions for natural cultivation of Lactobacillus strains, which are also found in the natural microbiota of humans and animals from the Momchilovtsi area.
The centuries-old tradition of the local mountain inhabitants of consuming yoghurt with this strain has spread the region’s fame abroad, turning it into a mystical centre of longevity (because of the centenarians who lived there).
Its microbiological safety has been proven for centuries. - A scientific approach to exceptional quality:
- Discovery of Acad. prof. Maria Baltanjeva: Lactobacillus bulgaricus RM1 (Lactobacillus bulgaricus RM1) is the result of years of research conducted in the period 2015-2020 by the most distinguished scientist, microbiologist and researcher in the field of pure foods in Bulgaria, Acad. prof.. Maria Baltanjieva – has selected and evaluated Lactobacillus strains for over 60 years.
The aim of the research was to isolate and select a strain of Lactobacillus bougaricus with exceptional probiotic characteristics for an enhanced positive effect on our health.
The strain was selected according to the principle that scientists should not interfere with nature by genetic engineering, but discover and promote the best of it.
- Discovery of Acad. prof. Maria Baltanjeva: Lactobacillus bulgaricus RM1 (Lactobacillus bulgaricus RM1) is the result of years of research conducted in the period 2015-2020 by the most distinguished scientist, microbiologist and researcher in the field of pure foods in Bulgaria, Acad. prof.. Maria Baltanjieva – has selected and evaluated Lactobacillus strains for over 60 years.
- Origin and tradition: Lactobacillus bulgaricus RM1 (Lactobacillus bulgaricus RM1) is the first selected and isolated probiotic strain from Momchilovtsi, Central Rhodopes in Bulgaria.
Tested with proven health benefits: the strain has been tested for morphological, physicochemical and biological indicators, with proven high survival and metabolic activity.
It is registered with the national bank in 2020 and its name is trademarked.
What makes Lactobacillus bulgaricus RM1 a high quality probiotic strain?
HIGH TOUGHNESS AND RESISTANCE
Lactobacillus bulgaricus RM1 (Lactobacillus bulgaricus RM1 ) has a high survival ability when it passes through the gastrointestinal tract.
RM1 Lactobacillus bulgaricus exhibits remarkable resistance to gastric acid and tolerance to bile salts.
It survives the conditions of the stomach and intestine, i.e. it has the ability to survive the acidic pH conditions in the stomach and to resist the effects of bile, i.e. it has adaptation or defence mechanisms that allow it to survive and perform its functions even in the presence of these acids.
The resistance of Lactobacillus bulgaricus RM1 to gastric acid is a fundamental property to be considered a strain with probiotic capabilities.
Study showed that Lactobacillus bulgaricus RM1 is resistant to harmful gastrointestinal conditions (pH 2.5, 0.2% bile salt solution and 0.4% phenol supplement); can survive for 90 minutes at pH 1.5)
EXCELLENT ABILITY TO REPRODUCE AND FORM COLONIES
Lactobacillus bulgaricus RM1 (Lactobacillus bulgaricus RM1) has an excellent ability to multiply in the gastrointestinal tract, primarily using the substrate to suppress and expel pathogenic and toxigenic microorganisms from their biological niche (environment). This is the preferred a way to suppress and eliminate pathogenic and toxigenic microorganisms.
This means that Lactobacillus bulgaricus RM1 uses specific substances in the gastrointestinal tract as a source of nutrients on which to grow and reproduce.
This process is important for maintaining healthy bacteria and for creating unfavorable conditions for the development of pathogens and toxins.
Microscopic image of LB RM1 after lyophilization
POWERFUL METABOLIC AND ANTIMICROBIAL ACTIVITY
By producing the enzyme lactase, Lactobacillus bulgaricus RM1 helps hydrolyse lactose, thereby aiding its better absorption.
The high proteolytic activity of the strain indicates its ability to hydrolyze (i.e. break down these proteins via water) accumulated toxic protein substances in the gastrointestinal tract and to interrupt the oxidative damage (harmful processes) caused by these proteins.
It has antimicrobial activity against potentially pathogenic, carcinogenic and pathogenic microorganisms, which is associated with deactivation of their enzyme systems, overcoming their adhesion (ability to attach to other cells), suppressing their growth and removing them from their biological niches.
NON-TOXIC/NON-PATHOGENIC/NON-INVASIVE
Lactobacillus bulgaricus PM1 has been shown to be non-pathogenic, non-toxic and non-invasive, so it can be safe for clinical and food applications. It poses no risk for disease, toxic effects or invasion. Non-invasive means that the strain does not penetrate or actively infiltrate other cells and does not cause infection or disrupt cell integrity.
This aspect is important because non-invasive probiotic strains can have beneficial effects on humans without causing undesirable consequences such as infection or cell damage .
EXCELLENT SYNERGY WITH SELECTED STRAINS TO ENHANCE HEALTH BENEFITS
Excellent withenergy with Lactobacillus rhamnosus и Str.
Thermophilus For:
- Strengthens the immune response for better protection against infections.Joint action with Lactobacillus rhamnosus improves the immune response and strengthens the immune response for better protection against infections.
- Antagonistic effect on Mycobacterium Tuberculosis Joint action with Str.
Thermophilus has an antagonistic effect on Mycobacterium Tuberculosis, which loses its virulence after 6 hours. - Has antithrombotic activity – under the action of Lactobacillus bulgaricus RM1 and Thermophilus functional peptides are produced that prevent the formation of thrombi in blood vessels
It has a bacteriostatic effect on bacteria of the genus Brucella, on Salmonella tiphirium, S. Enteritidis, S. choleraesis, Staphylococcus aureus, E. Coli.
This bacteriostatic effect of Lactobacillus bulgaricus results from its ability to produce bacteriocins and to synthesise specific substances.
Why should I take a probiotic with Lactobacillus bulgaricus RM1?
Lactobacillus bulgaricus RM1 is a strain with high individual and symbiotic activity with exceptional benefits for our health:
- Modulates the immune response
Modulates the body's immune response means that it has the ability to regulate or improve the body's immune response.
This can include both stimulating the immune system when necessary and regulating its activity to prevent excessive or unwanted immune responses.
Such a positive effect is beneficial to the general health and protection of the body from infection and disease. Lactobacillus bulgaricus RM1 activates the immune system and b-cell activity.
The mechanism of immunomodulation by the oligonucleotide OL-LB7 is related to the lymphoid tissue of the intestine, which plays an important role in mucosal immunity.
This type of immunity is based on various defense mechanisms that protect the body from infections and pathogens. - Extremely useful for restoring the gut microbiota after antibiotic treatment with resistance to most antibiotics commonly used in medical practice, without the risk of transferring genomic resistance from Lactobacillus bulgaricus RM1
Lactobacillus bulgaricus RM1 is resistant to most antibiotics, which means it can remain effective even after use themand not carried risk of transfer of antibiotic resistance into the genome ( i.e. when bacteria become resistant to antibiotics, this type of resistance can theoretically be passed on to other bacteria through genetic transfer). This is a desirable property, especially when it comes to microorganisms that can be used in food or The Pharmaceutical
industry. - Positively affects metabolic activity
Lactobacillus bulgaricus RM1 has a positive effect on the metabolic activity of the organism.
This probiotic strain supports metabolism, i.e. the processes of metabolism in the body, which can have a beneficial effect on general health. - Highly proteolytic strain enzymes support muscle, joint and general tissue health
Lactobacillus bulgaricus RM1 contains highly proteolytic enzymes that aid in protein breakdown.
This process can have a positive effect on muscle, joint and joint tissue health.
Proteolytic enzymes aid in protein breakdown and may be beneficial for overall tissue function and health. - Prevents plaque formation in blood vessels
Consumption of Lactobacillus bulgaricus RM1reducesthe amount of fatty acids produced by the breakdown of protein substances.
And fatty acids can form plaques on blood vessels by reducing blood patency. - Produces antimicrobial substances
Lactobacillus bulgaricus RM1 produces antimicrobial substances that inhibit harmful microorganisms in the intestinal microflora.
It has a pronounced bacteriostatic effect on various pathogens, for example, significantly reducing the number of species of the genus CLostridium in the intestinal tract. Clostridium genus members degrade amino acids, which produces toxic substances-ammonia, indole and phenol, which provoke lowering of the immune system and intestinal disease.The suppression of pathogenic microorganisms is believed to be due to the hydrogen peroxide that Lactobacillus bulgaricus RM1synthesizesand limits or stops the development of psychrotrophic bacteria of the species: genus Salmonella, S. Typhimurium, Staphylococcus aureus, Esch.
Coli, Clostridium, genera Pseudomonas, Bacillus, Streptococcus, Saracina u Mycobacterium. - Reduces changes on DNA induced by chemical mutagens
Constituents inhibiting the growth of certain tumor cells have been isolated from the cell wall of Lactobacillus bulgaricus RM1.
